Therapeutic areas

Recruiting for rheumatoid arthritis trials through rheumatologists

Older woman shaping clay on a pottery wheel in a sunlit studio
Short answerRheumatologists are the core referral source for rheumatoid arthritis trials because they confirm the diagnosis and track disease activity and prior treatments, which usually decide eligibility. Primary care physicians are a secondary source for early or undiagnosed disease. The referral summary should state the disease activity threshold and which prior therapies are required or excluded.

Which physicians refer to rheumatoid arthritis trials?

  • Rheumatologists, who manage most patients with established disease.
  • Primary care physicians, for studies in early or newly diagnosed disease.
  • Orthopedic and hand specialists, who sometimes see patients before a rheumatology diagnosis.

What decides eligibility in most rheumatoid arthritis studies?

Usually three things a rheumatologist already knows: current disease activity, which prior therapies the patient has tried or failed, and how long they have been on their current treatment. With an average screen failure rate of 36.3% across therapeutic areas (Tufts CSDD), putting those criteria first in the physician summary is the simplest way to reduce wasted screens.

Why does speed matter in rheumatology?

Tufts CSDD found rheumatology among the therapeutic areas with the highest relative daily direct trial costs (PubMed). Sponsors value sites that bring in qualified patients quickly.

How do you keep rheumatologists referring?

Report back. Nearly 30% of physicians never hear from a site after referring (Tufts CSDD). A site that confirms each referral, explains why a patient did not qualify, and updates the physician on enrolled patients builds a lasting source (Applied Clinical Trials).

What should a rheumatoid arthritis outreach plan include?

  1. The core specialists and relevant primary care physicians within realistic driving distance of the site.
  2. A one page summary with the diagnosis requirements, key exclusions, procedures, and visit schedule.
  3. A named coordinator contact, and a commitment to report back on every referral.
  4. Follow up by email and LinkedIn, prioritizing physicians who engaged.

See referral strategy by therapeutic area for other conditions.

Get your study in front of the right local physicians

TrialNotice builds a physician referral pipeline around one active study. We identify relevant local physicians within driving distance of your site, send study aligned direct mail, follow up by email and LinkedIn, track engagement with recipient level QR codes, and route warm responses into your site team's workflow.

Talk to TrialNotice

Sources

  1. Applied Clinical Trials, "Can Recruitment and Retention Get Any Worse?" (Tufts CSDD screen failure study)
  2. Applied Clinical Trials, "Tufts CSDD Study Explores Low Recruitment Rates"
  3. Smith Z. et al., "New Estimates on the Cost of a Delay Day in Drug Development," PubMed
  4. Applied Clinical Trials, "Building a Physician Referral Network: A Case Study"