Therapeutic areas

Recruiting for obesity and type 2 diabetes trials through endocrinologists and primary care

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Short answerObesity and type 2 diabetes trials should target endocrinologists and primary care physicians together, since both manage large numbers of eligible patients, plus obesity medicine and bariatric specialists. The limiting factor is usually eligibility, not volume: lab ranges, current medications, and weight history decide most cases, so those belong at the top of the physician summary.

Which physicians refer to obesity and diabetes trials?

  • Primary care physicians, who manage most patients with type 2 diabetes and obesity.
  • Endocrinologists, for patients with more complex or poorly controlled disease.
  • Obesity medicine and bariatric specialists, for weight management studies.
  • Cardiologists and nephrologists, for studies focused on cardiovascular or kidney outcomes.

What causes screen failure in these trials?

With a large patient pool, the challenge is matching, not finding. Across all therapeutic areas, Tufts CSDD puts the average screen failure rate at 36.3% (Tufts CSDD). In metabolic studies, the criteria that decide most cases are usually already in the referring physician's chart:

  • HbA1c or BMI ranges.
  • Current and recent diabetes or weight loss medications.
  • Kidney function and other lab thresholds.

What should the physician summary say?

List the lab ranges and medication exclusions in the first lines, then the visit schedule. Physicians name missing information and time as their main reasons for not referring (Tufts CSDD). The more of the matching they can do from memory, the more qualified the referrals.

Do patients want to hear about these trials from their doctor?

Yes. In CISCRP's 2017 study, 58% of people said they would begin a clinical trial search by asking their doctor (CISCRP). Patients managing a chronic condition see their physician regularly, which gives referral outreach many chances to land.

What should a obesity and diabetes outreach plan include?

  1. The core specialists and relevant primary care physicians within realistic driving distance of the site.
  2. A one page summary with the diagnosis requirements, key exclusions, procedures, and visit schedule.
  3. A named coordinator contact, and a commitment to report back on every referral.
  4. Follow up by email and LinkedIn, prioritizing physicians who engaged.

See referral strategy by therapeutic area for other conditions.

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Sources

  1. Applied Clinical Trials, "Can Recruitment and Retention Get Any Worse?" (Tufts CSDD screen failure study)
  2. Applied Clinical Trials, "Tufts CSDD Study Explores Low Recruitment Rates"
  3. CISCRP, 2017 Perceptions and Insights Study: Decision Making Process